Ontology highlight
ABSTRACT:
SUBMITTER: Stadtmann A
PROVIDER: S-EPMC4506862 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Stadtmann Anika A Block Helena H Volmering Stephanie S Abram Clare C Sohlbach Charlotte C Boras Mark M Lowell Clifford A CA Zarbock Alexander A
Journal of immunology (Baltimore, Md. : 1950) 20150622 3
Neutrophil recruitment to the site of inflammation plays a pivotal role in host defense. However, overwhelming activation and accumulation of neutrophils in the tissue may cause tissue damage and autoimmunity due to the release of cytokines, oxidants, and proteases. Neutrophil adhesion in acute inflammation is initiated by activation of αLβ2 (LFA-1), which can be induced by rolling on E-selectin (slowly) or by exposure to the chemokine CXCL1 (rapidly). Despite the clinical importance, cell-intri ...[more]