Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4506880 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wang Yuan Y Miwa Takashi T Ducka-Kokalari Blerina B Redai Imre G IG Sato Sayaka S Gullipalli Damodar D Zangrilli James G JG Haczku Angela A Song Wen-Chao WC
Journal of immunology (Baltimore, Md. : 1950) 20150626 3
Complement is implicated in asthma pathogenesis, but its mechanism of action in this disease remains incompletely understood. In this study, we investigated the role of properdin (P), a positive alternative pathway complement regulator, in allergen-induced airway inflammation. Allergen challenge stimulated P release into the airways of asthmatic patients, and P levels positively correlated with proinflammatory cytokines in human bronchoalveolar lavage (BAL). High levels of P were also detected i ...[more]