Ontology highlight
ABSTRACT:
SUBMITTER: Tan TC
PROVIDER: S-EPMC4507011 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Tan Tien-Chye TC Kracher Daniel D Gandini Rosaria R Sygmund Christoph C Kittl Roman R Haltrich Dietmar D Hällberg B Martin BM Ludwig Roland R Divne Christina C
Nature communications 20150707
A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-binding cytochrome (CYT) connected via a flexible linker to a flavin-dependent dehydrogenase (DH). Electrons are generated from cellobiose oxidation catalysed by DH and shuttled via C ...[more]