Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.

ABSTRACT:

Aim

To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients.

Methods

KIF1B protein and mRNA expression was assessed in HCC and paracarcinomatous (PC) tissues from 68 patients with HCC using Western blot and quantitative real-time reverse transcription-PCR, respectively. Student's t-tests were used to analyze relationships between clinicopathologic parameters and KIF1B expression, the Kaplan-Meier method was used to analyze survival outcomes, and the log-rank test was used to compare survival differences between groups.

Results

Mean protein and mRNA levels of KIF1B were similar between HCC and PC tissues. However, HCC tissues with vein invasions had significantly lower KIF1B prote

SUBMITTER: Yang SZ 

PROVIDER: S-EPMC4507112 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature