Design and Antigenic Epitopes Prediction of a New Trial Recombinant Multiepitopic Rotaviral Vaccine: In Silico Analyses.
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SUBMITTER: Jafarpour S
PROVIDER: S-EPMC4507124 | biostudies-literature | 2015 Jul-Aug
REPOSITORIES: biostudies-literature
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Design and Antigenic Epitopes Prediction of a New Trial Recombinant Multiepitopic Rotaviral Vaccine: In Silico Analyses.
Jafarpour Sima S Ayat Hoda H Ahadi Ali Mohammad AM
Viral immunology 20150512 6
Rotavirus is the major etiologic factor of severe diarrheal disease. Natural infection provides protection against subsequent rotavirus infection and diarrhea. This research presents a new vaccine designed based on computational models. In this study, three types of epitopes are considered-linear, conformational, and combinational-in a proposed model protein. Several studies on rotavirus vaccines have shown that VP6 and VP4 proteins are good candidates for vaccine production. In the present stud ...[more]
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