Ontology highlight
ABSTRACT:
SUBMITTER: Moshkovits I
PROVIDER: S-EPMC4507247 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Moshkovits Itay I Karo-Atar Danielle D Itan Michal M Reichman Hadar H Rozenberg Perri P Morgenstern-Ben-Baruch Netali N Shik Dana D Ejarque-Ortiz Aroa A Hershko Alon Y AY Tian Linjie L Coligan John E JE Sayós Joan J Munitz Ariel A
Proceedings of the National Academy of Sciences of the United States of America 20150629 28
IL-4 receptor (R) α, the common receptor chain for IL-4 and IL-13, is a critical component in IL-4- and IL-13-mediated signaling and subsequent effector functions such as those observed in type 2 inflammatory responses. Nonetheless, the existence of intrinsic pathways capable of amplifying IL-4Rα-induced responses remains unknown. In this study, we identified the myeloid-associated Ig receptor CD300f as an IL-4-induced molecule in macrophages. Subsequent analyses demonstrated that CD300f was col ...[more]