Unknown

Dataset Information

0

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.

ABSTRACT: The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

SUBMITTER: Pandya DN 

PROVIDER: S-EPMC4507282 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.

Pandya Darpan N DN   Pailloux Sylvie S   Tatum David D   Magda Darren D   Wadas Thaddeus J TJ  

Chemical communications (Cambridge, England) 20150201 12

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr. ...[more]

Similar Datasets

Unknown Evaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89.
| S-EPMC5456358 | biostudies-literature
Unknown Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89.
| S-EPMC6468543 | biostudies-literature
Unknown Zirconium-89 labeled panitumumab: a potential immuno-PET probe for HER1-expressing carcinomas.
| S-EPMC3637856 | biostudies-other
Unknown Biodistribution and PET imaging of 89-zirconium labeled cerium oxide nanoparticles synthesized with several surface coatings.
| S-EPMC6175665 | biostudies-literature
Unknown Noise-Induced Variability of Immuno-PET with Zirconium-89-Labeled Antibodies: an Analysis Based on Count-Reduced Clinical Images.
| S-EPMC6244539 | biostudies-literature
Unknown Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units.
| S-EPMC3685440 | biostudies-literature
Unknown Immuno-PET Imaging of the Programmed Cell Death-1 Ligand (PD-L1) Using a Zirconium-89 Labeled Therapeutic Antibody, Avelumab.
| S-EPMC6498777 | biostudies-literature
Unknown Tuning the properties of tris(hydroxypyridinone) ligands: efficient <sup>68</sup>Ga chelators for PET imaging.
| S-EPMC6469224 | biostudies-literature
Unknown Promising Performance of 4HMS, a New Zirconium-89 Octadendate Chelator.
| S-EPMC7240819 | biostudies-literature
Unknown Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B.
| S-EPMC4357251 | biostudies-literature