Ontology highlight
ABSTRACT:
SUBMITTER: Zhu SJ
PROVIDER: S-EPMC4507787 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhu Shu Jun SJ Hallows Stephanie E SE Currie Ko W KW Xu ChangJiang C Pearson Bret J BJ
eLife 20150626
Neoblasts are adult stem cells (ASCs) in planarians that sustain cell replacement during homeostasis and regeneration of any missing tissue. While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving postmitotic fates remain poorly defined. In this study, we used transcriptional profiling of irradiation-sensitive and irradiation-insensitive cell populations and RNA interference (RNAi) functional screening to uncover markers and regulators of postmitot ...[more]