Ontology highlight
ABSTRACT:
SUBMITTER: Kubiczkova L
PROVIDER: S-EPMC4508135 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kubiczkova Lenka L Pour Ludek L Sedlarikova Lenka L Hajek Roman R Sevcikova Sabina S
Journal of cellular and molecular medicine 20140408 6
Inhibition of proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, has emerged as a powerful strategy for treatment of multiple myeloma (MM), a plasma cell malignancy. First-in-class agent, bortezomib, has demonstrated great positive therapeutic efficacy in MM, both in pre-clinical and in clinical studies. However, despite its high efficiency, a large proportion of patients do not achieve sufficient clinical response. Therefore, the development of a second ...[more]