Ontology highlight
ABSTRACT:
SUBMITTER: Sugahara KN
PROVIDER: S-EPMC4508207 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Sugahara Kazuki N KN Scodeller Pablo P Braun Gary B GB de Mendoza Tatiana Hurtado TH Yamazaki Chisato M CM Kluger Michael D MD Kitayama Joji J Alvarez Edwin E Howell Stephen B SB Teesalu Tambet T Ruoslahti Erkki E Lowy Andrew M AM
Journal of controlled release : official journal of the Controlled Release Society 20150611
Peritoneal carcinomatosis is a major source of morbidity and mortality in patients with advanced abdominal neoplasms. Intraperitoneal chemotherapy (IPC) is an area of intense interest given its efficacy in ovarian cancer. However, IPC suffers from poor drug penetration into peritoneal tumors. As such, extensive cytoreductive surgery is required prior to IPC. Here, we explore the utility of iRGD, a tumor-penetrating peptide, for improved tumor-specific penetration of intraperitoneal compounds and ...[more]