Ontology highlight
ABSTRACT:
SUBMITTER: Ha Thi HT
PROVIDER: S-EPMC4508311 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ha Thi Huyen Trang HT Kim Hye-Youn HY Choi Seo-Won SW Kang Jin-Muk JM Kim Seong-Jin SJ Hong Suntaek S
Molecular and cellular biology 20150608 16
Epidermal growth factor (EGF) regulates various cellular events, including proliferation, differentiation, migration, and tumorigenesis. For the maintenance of homeostasis, EGF signaling should be tightly regulated to prevent the aberrant activation. Smad7 has been known as inhibitory Smad that blocks the signal transduction of transforming growth factor β. In the process of cell proliferation or transformation, Smad7 has been shown the opposite activities as a promoter or suppressor depending o ...[more]