CIN85 modulates TGF? signaling by promoting the presentation of TGF? receptors on the cell surface.
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ABSTRACT:
SUBMITTER: Yakymovych I
PROVIDER: S-EPMC4508896 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.
Yakymovych Ihor I Yakymovych Mariya M Zang Guangxiang G Mu Yabing Y Bergh Anders A Landström Maréne M Heldin Carl-Henrik CH
The Journal of cell biology 20150713 2
Members of the transforming growth factor β (TGFβ) family initiate cellular responses by binding to TGFβ receptor type II (TβRII) and type I (TβRI) serine/threonine kinases, whereby Smad2 and Smad3 are phosphorylated and activated, promoting their association with Smad4. We report here that TβRI interacts with the SH3 domains of the adaptor protein CIN85 in response to TGFβ stimulation in a TRAF6-dependent manner. Small interfering RNA-mediated knockdown of CIN85 resulted in accumulation of TβRI ...[more]
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