Ontology highlight
ABSTRACT:
SUBMITTER: Bamidele AO
PROVIDER: S-EPMC4508899 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Bamidele Adebowale O AO Kremer Kimberly N KN Hirsova Petra P Clift Ian C IC Gores Gregory J GJ Billadeau Daniel D DD Hedin Karen E KE
The Journal of cell biology 20150701 2
IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a cytoskeleton-interacting scaffold protein. CXCR4 is a chemokine receptor that binds stromal cell-derived factor-1 (SDF-1; also known as CXCL12). Both IQGAP1 and CXCR4 are overexpressed in cancer cell types, yet it was unclear whether these molecules functionally interact. Here, we show that depleting IQGAP1 in Jurkat T leukemic cells reduced CXCR4 expression, disrupted trafficking of endocytosed CXCR4 via EEA-1(+) endosomes, and decre ...[more]