Dataset Information

Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

ABSTRACT: BACKGROUND:Previous studies suggested the single nucleotide polymorphism (SNP) of COX-2 -765G>C (rs20417) is associated with coronary artery disease (CAD), but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between rs20417 and CAD in all published studies. METHOD:Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs).The statistical tests were performed using Review Manager 5.3.3 and Stata 12.0 software. RESULTS:We identified a total of 14 studies involving a total of 18227 subjects. The pooled odds ratio (OR) for the association between COX-2 -765G>C and CAD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect model. A significant statistical association between COX-2 -765G>C and CAD was observed in an allelic model (P=0.02, OR=0.64, 95% CI: 0.43-0.94), dominant model (P=0.04, OR=0.74, 95% CI: 0.56-0.99), and recessive model (P=0.02, OR=0.46, 95% CI: 0.23-0.90). CONCLUSION:This meta-analysis suggested that COX-2 -765G>C is a protective for CAD.

SUBMITTER: Zhang MM

PROVIDER: S-EPMC4509228 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

Zhang Ming-Ming MM Xie Xiang X Ma Yi-Tong YT Zheng Ying-Ying YY Yang Yi-Ning YN Li Xiao-Mei XM Fu Zhen-Yan ZY Liu Fen F Chen Bang-Dang BD

International journal of clinical and experimental medicine 20150515 5

<h4>Background</h4>Previous studies suggested the single nucleotide polymorphism (SNP) of COX-2 -765G>C (rs20417) is associated with coronary artery disease (CAD), but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between rs20417 and CAD in all published studies.<h4>Method</h4>Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. Data were extracted usi ...[more]

PMID: 26221283

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Project description:The receptor for advanced glycosylation end products (RAGE) has been widely linked to diabetic atherosclerosis, but its effects on coronary artery disease (CAD) and ischemic stroke (IS) remain controversial. The Gly82Ser polymorphism is located in the ligand-binding V domain of RAGE, suggesting a possible influence of this variant on RAGE function. The aim of the present study is to clarify the association between the RAGE Gly82Ser polymorphism and susceptibility to CAD and IS.Eligible studies were identified through a comprehensive literature search. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association of Gly82Ser polymorphism with CAD and IS risk. Fixed- or random-effects model was used depending on the heterogeneity between studies. A funnel plot and Egger linear regression test were applied to assess publication bias. We also performed subgroup analyses to investigate potential sources of heterogeneity.A total of 16 eligible articles containing 18 studies were analyzed. The pooled analysis indicated that the Gly82Ser polymorphism significantly increased CAD risk in recessive and homozygous genetic models (SS vs GS?+?GG: OR = 1.34, 95% CI = 1.09-1.64; SS vs GG: OR = 1.38, 95% CI = 1.12-1.71). A significant association between the Gly82Ser polymorphism and IS risk was observed in all tested models except the heterozygous genetic model (GS?+?SS vs GG: OR = 1.20, 95% CI = 1.04-1.38; SS vs GS?+?GG: OR = 2.20, 95% CI = 1.74-2.78; SS vs GG: OR = 2.23, 95% CI = 1.72-2.91; S vs G: OR = 1.32, 95% CI = 1.05-1.65). Subgroup analysis suggested an association between CAD and IS risk and the Gly82Ser polymorphism in the Chinese population, but not in the non-Chinese population.The current meta-analysis suggests that the RAGE Gly82Ser polymorphism is associated with an increased risk of CAD and IS, especially in the Chinese population. However, better-designed studies with larger sample sizes are needed to validate the results.

Dataset Information

Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

Publications

Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

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