Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis.

ABSTRACT: BACKGROUND:Previous studies suggested the single nucleotide polymorphism (SNP) of COX-2 -765G>C (rs20417) is associated with coronary artery disease (CAD), but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between rs20417 and CAD in all published studies. METHOD:Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs).The statistical tests were performed using Review Manager 5.3.3 and Stata 12.0 software. RESULTS:We identified a total of 14 studies involving a total of 18227 subjects. The pooled odds ratio (OR) for the association between COX-2 -765G>C and CAD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect model. A significant statistical association between COX-2 -765G>C and CAD was observed in an allelic model (P=0.02, OR=0.64, 95% CI: 0.43-0.94), dominant model (P=0.04, OR=0.74, 95% CI: 0.56-0.99), and recessive model (P=0.02, OR=0.46, 95% CI: 0.23-0.90). CONCLUSION:This meta-analysis suggested that COX-2 -765G>C is a protective for CAD.

SUBMITTER: Zhang MM 

PROVIDER: S-EPMC4509228 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature