Ontology highlight
ABSTRACT:
SUBMITTER: Pagan AJ
PROVIDER: S-EPMC4509513 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pagán Antonio J AJ Yang Chao-Tsung CT Cameron James J Swaim Laura E LE Ellett Felix F Lieschke Graham J GJ Ramakrishnan Lalita L
Cell host & microbe 20150701 1
The mycobacterial ESX-1 virulence locus accelerates macrophage recruitment to the forming tuberculous granuloma. Newly recruited macrophages phagocytose previously infected apoptotic macrophages to become new bacterial growth niches. Granuloma macrophages can then necrose, releasing mycobacteria into the extracellular milieu, which potentiates their growth even further. Using zebrafish with genetic or pharmacologically induced macrophage deficiencies, we find that global macrophage deficits incr ...[more]