Ontology highlight
ABSTRACT:
SUBMITTER: Whiting CC
PROVIDER: S-EPMC4509650 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Whiting Chan C CC Siebert Janet J Newman Aaron M AM Du Hong-Wu HW Alizadeh Ash A AA Goronzy Jorg J Weyand Cornelia M CM Krishnan Eswar E Fathman C Garrison CG Maecker Holden T HT
PloS one 20150721 7
While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly heterogeneous across individuals, many of these assays revealed trends by age, sex, and CMV st ...[more]