Unknown

Dataset Information

0

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.


ABSTRACT: While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly heterogeneous across individuals, many of these assays revealed trends by age, sex, and CMV status, to greater or lesser degrees. Age, then sex and CMV status, showed the greatest impact on the immune system, as measured by the percentage of assay readouts with significant differences. An elastic net regression model could optimally predict age with 14 analytes from different assays. This reinforces the importance of multivariate analysis for defining a healthy immune system. These data provide a reference for others measuring immune parameters in older people.

SUBMITTER: Whiting CC 

PROVIDER: S-EPMC4509650 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.

Whiting Chan C CC   Siebert Janet J   Newman Aaron M AM   Du Hong-Wu HW   Alizadeh Ash A AA   Goronzy Jorg J   Weyand Cornelia M CM   Krishnan Eswar E   Fathman C Garrison CG   Maecker Holden T HT  

PloS one 20150721 7


While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly heterogeneous across individuals, many of these assays revealed trends by age, sex, and CMV st  ...[more]

Similar Datasets

| S-EPMC3925390 | biostudies-literature
| S-EPMC1193581 | biostudies-literature
| S-EPMC6971086 | biostudies-literature
| S-EPMC6634426 | biostudies-literature
| S-EPMC8744674 | biostudies-literature
2018-11-30 | GSE107483 | GEO
| S-EPMC8701385 | biostudies-literature
| S-EPMC5861915 | biostudies-literature
| S-EPMC5006906 | biostudies-other
| S-EPMC6526898 | biostudies-literature