Ontology highlight
ABSTRACT:
SUBMITTER: Pothapragada S
PROVIDER: S-EPMC4509790 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Pothapragada Seetha S Zhang Peng P Zhang Peng P Sheriff Jawaad J Livelli Mark M Slepian Marvin J MJ Deng Yuefan Y Bluestein Danny D
International journal for numerical methods in biomedical engineering 20150301 3
We developed a phenomenological three-dimensional platelet model to characterize the filopodia formation observed during early stage platelet activation. Departing from continuum mechanics based approaches, this coarse-grained molecular dynamics (CGMD) particle-based model can deform to emulate the complex shape change and filopodia formation that platelets undergo during activation. The platelet peripheral zone is modeled with a two-layer homogeneous elastic structure represented by spring-conn ...[more]