Ontology highlight
ABSTRACT:
SUBMITTER: Mirza RE
PROVIDER: S-EPMC4509817 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Mirza Rita E RE Fang Milie M MM Novak Margaret L ML Urao Norifumi N Sui Audrey A Ennis William J WJ Koh Timothy J TJ
The Journal of pathology 20150512 4
Macrophages undergo a transition from pro-inflammatory to healing-associated phenotypes that is critical for efficient wound healing. However, the regulation of this transition during normal and impaired healing remains to be elucidated. In our studies, the switch in macrophage phenotypes during skin wound healing was associated with up-regulation of the peroxisome proliferator-activated receptor (PPAR)γ and its downstream targets, along with increased mitochondrial content. In the setting of di ...[more]