Prediction error and trace dominance determine the fate of fear memories after post-training manipulations.

ABSTRACT: Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization-reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memorie

SUBMITTER: Alfei JM 

PROVIDER: S-EPMC4509917 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature