Ontology highlight
ABSTRACT:
SUBMITTER: Hossain A
PROVIDER: S-EPMC4509942 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Hossain Anwar A Gumin Joy J Gao Feng F Figueroa Javier J Shinojima Naoki N Takezaki Tatsuya T Priebe Waldemar W Villarreal Diana D Kang Seok-Gu SG Joyce Celine C Sulman Erik E Wang Qianghu Q Marini Frank C FC Andreeff Michael M Colman Howard H Lang Frederick F FF
Stem cells (Dayton, Ohio) 20150527 8
Although mesenchymal stem cells (MSCs) have been implicated as stromal components of several cancers, their ultimate contribution to tumorigenesis and their potential to drive cancer stem cells, particularly in the unique microenvironment of human brain tumors, remain largely undefined. Consequently, using established criteria, we isolated glioma-associated-human MSCs (GA-hMSCs) from fresh human glioma surgical specimens for the first time. We show that these GA-hMSCs are nontumorigenic stromal ...[more]