Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation.
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ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC4510476 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation.
Gao Xiugong X Sprando Robert L RL Yourick Jeffrey J JJ
Data in brief 20150603
Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled "Thalidomide induced early gene expression perturbations indic ...[more]
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