Ontology highlight
ABSTRACT:
SUBMITTER: Ozmadenci D
PROVIDER: S-EPMC4510695 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Ozmadenci Duygu D Féraud Olivier O Markossian Suzy S Kress Elsa E Ducarouge Benjamin B Gibert Benjamin B Ge Jian J Durand Isabelle I Gadot Nicolas N Plateroti Michela M Bennaceur-Griscelli Annelise A Scoazec Jean-Yves JY Gil Jesus J Deng Hongkui H Bernet Agnes A Mehlen Patrick P Lavial Fabrice F
Nature communications 20150708
The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cell ...[more]