Histone modifications predispose genome regions to breakage and translocation.
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ABSTRACT:
SUBMITTER: Burman B
PROVIDER: S-EPMC4511214 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Histone modifications predispose genome regions to breakage and translocation.
Burman Bharat B Zhang Zhuzhu Z ZZ Pegoraro Gianluca G Lieb Jason D JD Misteli Tom T
Genes & development 20150623 13
Chromosome translocations are well-established hallmarks of cancer cells and often occur at nonrandom sites in the genome. The molecular features that define recurrent chromosome breakpoints are largely unknown. Using a combination of bioinformatics, biochemical analysis, and cell-based assays, we identify here specific histone modifications as facilitators of chromosome breakage and translocations. We show enrichment of several histone modifications over clinically relevant translocation-prone ...[more]
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