Ontology highlight
ABSTRACT:
SUBMITTER: Michel AK
PROVIDER: S-EPMC4511962 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20140819 14
By using lactose-functionalized poly(amidoamine) dendrimers as a tunable multivalent platform, we studied cancer cell aggregation in three different cell lines (A549, DU-145, and HT-1080) with galectin-3. We found that small lactose-functionalized G(2)-dendrimer 1 inhibited galectin-3-induced aggregation of the cancer cells. In contrast, dendrimer 4 (a larger, generation 6 dendrimer with 100 carbohydrate end groups) caused cancer cells to aggregate through a galectin-3 pathway. This study indica ...[more]