Ontology highlight
ABSTRACT:
SUBMITTER: Atilano SR
PROVIDER: S-EPMC4512622 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Atilano Shari R SR Malik Deepika D Chwa Marilyn M Cáceres-Del-Carpio Javier J Nesburn Anthony B AB Boyer David S DS Kuppermann Baruch D BD Jazwinski S Michal SM Miceli Michael V MV Wallace Douglas C DC Udar Nitin N Kenney M Cristina MC
Human molecular genetics 20150510 16
Mitochondrial (mt) DNA can be classified into haplogroups representing different geographic and/or racial origins of populations. The H haplogroup is protective against age-related macular degeneration (AMD), while the J haplogroup is high risk for AMD. In the present study, we performed comparison analyses of human retinal cell cybrids, which possess identical nuclei, but mtDNA from subjects with either the H or J haplogroups, and demonstrate differences in total global methylation, and express ...[more]