Ontology highlight
ABSTRACT:
SUBMITTER: Pfister SM
PROVIDER: S-EPMC4512653 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Acta neuropathologica 20100930 5
Tremendous progress has recently been made in both molecular subgrouping, and the establishment of prognostic biomarkers for embryonal brain tumors, particularly medulloblastoma. Several prognostic biomarkers that were initially identified in retrospective cohorts of medulloblastoma, including MYC and MYCN amplification, nuclear β-catenin accumulation, and chromosome 17 aberrations have now been validated in clinical trials. Moreover, molecular subgroups based on distinct transcriptome profiles ...[more]