Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC4512754 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Yang Haijuan H Rudge Derek G DG Koos Joseph D JD Vaidialingam Bhamini B Yang Hyo J HJ Pavletich Nikola P NP
Nature 20130501 7448
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in cancer. Here we report co-crystal structures of a complex of truncated mTOR and mammalian lethal with SEC13 protein 8 (mLST8) with an ATP transition state mimic and with ATP-site inhibitors. The structures reveal an intrinsically active kinase conformation, with catalytic residues and a catalytic mechanism ...[more]