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Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.


ABSTRACT: To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.

SUBMITTER: Yao Y 

PROVIDER: S-EPMC4512951 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.

Yao Yibing Y   Fan Yu Y   Wu Jun J   Wan Haisu H   Wang Jing J   Lam Stephen S   Lam Wan L WL   Girard Luc L   Gazdar Adi F AF   Wu Zhihao Z   Zhou Qinghua Q  

Biochemical and biophysical research communications 20120616 3


To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies th  ...[more]

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