Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4513566 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhang Yue Y Sun Ying Y Ding Guixia G Huang Songming S Zhang Aihua A Jia Zhanjun Z
Scientific reports 20150724
Ureteral obstruction with subsequent hydronephrosis is a common clinical complication. Downregulation of renal sodium transporters in obstructed kidneys could contribute to impaired urinary concentrating capability and salt waste following the release of a ureteral obstruction. The current study was undertaken to investigate the role of mitochondrial complex-1 inhibition in modulating sodium transporters in obstructive kidney disease. Following unilateral ureteral obstruction (UUO) for 7 days, a ...[more]