Malaria invasion ligand RH5 and its prime candidacy in blood-stage malaria vaccine design.

ABSTRACT: With drug resistance to available therapeutics continuing to develop against Plasmodium falciparum malaria, the development of an effective vaccine candidate remains a major research goal. Successful interruption of invasion of parasites into erythrocytes during the blood stage of infection will prevent the severe clinical symptoms and complications associated with malaria. Previously studied blood stage antigens have highlighted the hurdles that are inherent to this life-cycle stage, namely that highly immunogenic antigens are also globally diverse, resulting in protection only against the vaccine strain, or that naturally acquired immunity to blood stage antigens do not always correlate with actual protection. The blood stage antigen reticulocyte binding homolog RH5 is essential for para

SUBMITTER: Ord RL 

PROVIDER: S-EPMC4514319 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature