Ontology highlight
ABSTRACT:
SUBMITTER: Jones RM
PROVIDER: S-EPMC4514342 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Human vaccines & immunotherapeutics 20141101 1
Malaria transmission blocking vaccines (TBV) directed against proteins expressed on sexual stages of Plasmodium falciparum in the mosquito midgut are considered an effective means to reduce malaria transmission. Antibodies induced by TBV block sporogonic development in the mosquito, and thus transmission to the next human host. The Pfs25 protein, expressed on the surface of gametes, zygotes and ookinetes, is one of the primary targets for TBV development. Using a plant virus-based transient expr ...[more]