Ontology highlight
ABSTRACT:
SUBMITTER: Rhim AD
PROVIDER: S-EPMC4514438 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Rhim Andrew D AD Thege Fredrik I FI Santana Steven M SM Lannin Timothy B TB Saha Trisha N TN Tsai Shannon S Maggs Lara R LR Kochman Michael L ML Ginsberg Gregory G GG Lieb John G JG Chandrasekhara Vinay V Drebin Jeffrey A JA Ahmad Nuzhat N Yang Yu-Xiao YX Kirby Brian J BJ Stanger Ben Z BZ
Gastroenterology 20131213 3
Hematogenous dissemination is thought to be a late event in cancer progression. We recently showed in a genetic model of pancreatic ductal adenocarcinoma that pancreas cells can be detected in the bloodstream before tumor formation. To confirm these findings in humans, we used microfluidic geometrically enhanced differential immunocapture to detect circulating pancreas epithelial cells in patient blood samples. We captured more than 3 circulating pancreas epithelial cells/mL in 7 of 21 (33%) pat ...[more]