Ontology highlight
ABSTRACT:
SUBMITTER: Kang S
PROVIDER: S-EPMC4514563 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20150710 14
We have analyzed a recently obtained crystal structure of human neuronal nitric oxide synthase (nNOS) and then designed and synthesized several 2-aminopyridine derivatives containing a truncated side chain to avoid the hydrophobic pocket that differentiates human and rat nNOS in an attempt to explore alternative binding poses along the substrate access channel of human nNOS. Introduction of an N-methylethane-1,2-diamine side chain and conformational constraints such as benzonitrile and pyridine ...[more]