Ontology highlight
ABSTRACT:
SUBMITTER: Pirinen M
PROVIDER: S-EPMC4514921 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Pirinen Matti M Lappalainen Tuuli T Zaitlen Noah A NA Dermitzakis Emmanouil T ET Donnelly Peter P McCarthy Mark I MI Rivas Manuel A MA
Bioinformatics (Oxford, England) 20150327 15
<h4>Motivation</h4>RNA sequencing enables allele-specific expression (ASE) studies that complement standard genotype expression studies for common variants and, importantly, also allow measuring the regulatory impact of rare variants. The Genotype-Tissue Expression (GTEx) project is collecting RNA-seq data on multiple tissues of a same set of individuals and novel methods are required for the analysis of these data.<h4>Results</h4>We present a statistical method to compare different patterns of ...[more]