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Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant.

ABSTRACT: BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ?10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.

SUBMITTER: Laskin BL 

PROVIDER: S-EPMC4515143 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant.

Laskin Benjamin L BL   Sullivan Kathleen E KE   Hester Jeff J   Goebel Jens J   Davies Stella M SM   Jodele Sonata S  

Pediatric blood & cancer 20150401 9

BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence  ...[more]

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