Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways.
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ABSTRACT:
SUBMITTER: Mocarski ES
PROVIDER: S-EPMC4515451 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways.
Mocarski Edward S ES Upton Jason W JW Kaiser William J WJ
Nature reviews. Immunology 20111223 2
Pathogens specifically target both the caspase 8-dependent apoptotic cell death pathway and the necrotic cell death pathway that is dependent on receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3). The fundamental co-regulation of these two cell death pathways emerged when the midgestational death of mice deficient in FAS-associated death domain protein (FADD) or caspase 8 was reversed by elimination of RIP1 or RIP3, indicating a far more entwined relationsh ...[more]
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