Genetics, Epigenetics, and Genomics of Systemic Sclerosis.
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ABSTRACT:
SUBMITTER: Salazar G
PROVIDER: S-EPMC4515564 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Genetics, Epigenetics, and Genomics of Systemic Sclerosis.
Salazar Gloria G Mayes Maureen D MD
Rheumatic diseases clinics of North America 20150520 3
Systemic sclerosis (SSc) is a complex autoimmune disease that occurs in a genetically susceptible host. Genetic studies performed so far reveal that multiple genetic loci contribute to disease susceptibility in SSc. The purpose of this review is to discuss the current knowledge of genetics in SSc by exploring the observational evidence, the different genetic studies, and their modalities as well as the most relevant genes discovered by these. The importance of gene expression variation and the d ...[more]
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