Ontology highlight
ABSTRACT:
SUBMITTER: Martins WK
PROVIDER: S-EPMC4515638 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Martins Waleska K WK Costa Érico T ÉT Cruz Mário C MC Stolf Beatriz S BS Miotto Ronei R Cordeiro Rodrigo M RM Baptista Maurício S MS
Scientific reports 20150727
The role of autophagy in cell death is still controversial and a lot of debate has concerned the transition from its pro-survival to its pro-death roles. The similar structure of the triterpenoids Betulinic (BA) and Oleanolic (OA) acids allowed us to prove that this transition involves parallel damage in mitochondria and lysosome. After treating immortalized human skin keratinocytes (HaCaT) with either BA or OA, we evaluated cell viability, proliferation and mechanism of cell death, function and ...[more]