Ontology highlight
ABSTRACT:
SUBMITTER: Kandasamy K
PROVIDER: S-EPMC4515747 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kandasamy Karthikeyan K Chuah Jacqueline Kai Chin JK Su Ran R Huang Peng P Eng Kim Guan KG Xiong Sijing S Li Yao Y Chia Chun Siang CS Loo Lit-Hsin LH Zink Daniele D
Scientific reports 20150727
The renal proximal tubule is a main target for drug-induced toxicity. The prediction of proximal tubular toxicity during drug development remains difficult. Any in vitro methods based on induced pluripotent stem cell-derived renal cells had not been developed, so far. Here, we developed a rapid 1-step protocol for the differentiation of human induced pluripotent stem cells (hiPSC) into proximal tubular-like cells. These proximal tubular-like cells had a purity of >90% after 8 days of differentia ...[more]