Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
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ABSTRACT:
SUBMITTER: Castillo JP
PROVIDER: S-EPMC4515779 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
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Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
Castillo Juan P JP Rui Huan H Basilio Daniel D Das Avisek A Roux Benoît B Latorre Ramon R Bezanilla Francisco F Holmgren Miguel M
Nature communications 20150724
The Na(+)/K(+)-ATPase restores sodium (Na(+)) and potassium (K(+)) electrochemical gradients dissipated by action potentials and ion-coupled transport processes. As ions are transported, they become transiently trapped between intracellular and extracellular gates. Once the external gate opens, three Na(+) ions are released, followed by the binding and occlusion of two K(+) ions. While the mechanisms of Na(+) release have been well characterized by the study of transient Na(+) currents, smaller ...[more]
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