Ontology highlight
ABSTRACT:
SUBMITTER: Lauria G
PROVIDER: S-EPMC4515982 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Lauria Giuseppe G Dalla Bella Eleonora E Antonini Giovanni G Borghero Giuseppe G Capasso Margherita M Caponnetto Claudia C Chiò Adriano A Corbo Massimo M Eleopra Roberto R Fazio Raffaella R Filosto Massimiliano M Giannini Fabio F Granieri Enrico E La Bella Vincenzo V Logroscino Giancarlo G Mandrioli Jessica J Mazzini Letizia L Monsurrò Maria Rosaria MR Mora Gabriele G Pietrini Vladimiro V Quatrale Rocco R Rizzi Romana R Salvi Fabrizio F Siciliano Gabriele G Sorarù Gianni G Volanti Paolo P Tramacere Irene I Filippini Graziella G
Journal of neurology, neurosurgery, and psychiatry 20150116 8
<h4>Objective</h4>To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40,000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Seconda ...[more]