Ontology highlight
ABSTRACT:
SUBMITTER: Gurevich VV
PROVIDER: S-EPMC4516159 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gurevich Vsevolod V VV Song Xiufeng X Vishnivetskiy Sergey A SA Gurevich Eugenia V EV
Handbook of experimental pharmacology 20140101
A variety of heritable and acquired disorders is associated with excessive signaling by mutant or overstimulated GPCRs. Since any conceivable treatment of diseases caused by gain-of-function mutations requires gene transfer, one possible approach is functional compensation. Several structurally distinct forms of enhanced arrestins that bind phosphorylated and even non-phosphorylated active GPCRs with much higher affinity than parental wild-type proteins have the ability to dampen the signaling b ...[more]