Ontology highlight
ABSTRACT:
SUBMITTER: Read AF
PROVIDER: S-EPMC4516275 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
PLoS biology 20150727 7
Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic str ...[more]