Ontology highlight
ABSTRACT:
SUBMITTER: Keck TM
PROVIDER: S-EPMC4516313 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20150331 14
The dopamine D3 receptor (D3R) is a target for developing medications to treat substance use disorders. D3R-selective compounds with high affinity and varying efficacies have been discovered, providing critical research tools for cell-based studies that have been translated to in vivo models of drug abuse. D3R antagonists and partial agonists have shown especially promising results in rodent models of relapse-like behavior, including stress-, drug-, and cue-induced reinstatement of drug seeking. ...[more]