Ontology highlight
ABSTRACT:
SUBMITTER: Aviles-Jimenez F
PROVIDER: S-EPMC451639 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Aviles-Jimenez Francisco F Letley Darren P DP Gonzalez-Valencia Gerardo G Salama Nina N Torres Javier J Atherton John C JC
Journal of bacteriology 20040801 15
We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity. ...[more]