Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

ABSTRACT: We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

SUBMITTER: Aviles-Jimenez F 

PROVIDER: S-EPMC451639 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature