PD-1/PD-L1 inhibitors.
Ontology highlight
ABSTRACT:
SUBMITTER: Sunshine J
PROVIDER: S-EPMC4516625 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Tumors may adopt normal physiologic checkpoints for immunomodulation leading to an imbalance between tumor growth and host surveillance. Antibodies targeting the PD-1/PD-L1 checkpoint have shown dynamic and durable tumor regressions, suggesting a rebalancing of the host-tumor interaction. Nivolumab and pembrolizumab are the anti-PD-1 antibodies that are currently the furthest in clinical development, and anti-PD-L1 agents under investigation include MPDL3280A, MEDI4736, and BMS-936559. These age ...[more]
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