Ontology highlight
ABSTRACT:
SUBMITTER: Voisinne G
PROVIDER: S-EPMC4516668 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Voisinne Guillaume G Nixon Briana G BG Melbinger Anna A Gasteiger Georg G Vergassola Massimo M Altan-Bonnet Grégoire G
Cell reports 20150501 8
T lymphocytes’ ability to discriminate between structurally related antigens has been attributed to the unique signaling properties of the T cell receptor. However, recent studies have suggested that the output of this discrimination process is conditioned by environmental cues. Here, we demonstrate how the IL-2 cytokine, collectively generated by strongly activated T cell clones, can induce weaker T cell clones to proliferate. We identify the PI3K pathway as being critical for integrating the a ...[more]