Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates.

ABSTRACT:

Background

Previous trials of prenatal iron supplementation had limited measures of maternal or neonatal iron status.

Objective

The purpose was to assess effects of prenatal iron-folate supplementation on maternal and neonatal iron status.

Methods

Enrollment occurred June 2009 through December 2011 in Hebei, China. Women with uncomplicated singleton pregnancies at ≤20 wk gestation, aged ≥18 y, and with hemoglobin ≥100 g/L were randomly assigned 1:1 to receive daily iron (300 mg ferrous sulfate) or placebo + 0.40 mg folate from enrollment to birth. Iron status was assessed in maternal venous blood (at enrollment and at or near term) and cord blood. Primary outcomes were as follows: 1) maternal iron deficiency (ID) defined in 2 ways as serum ferritin (SF) <15 μg/L and b

SUBMITTER: Zhao G 

PROVIDER: S-EPMC4516762 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature