Short Communication: Increase of HIV-1 K103N Transmitted Drug Resistance and Its Association with Efavirenz Use in South Korea.
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ABSTRACT:
SUBMITTER: Chin BS
PROVIDER: S-EPMC4516954 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Short Communication: Increase of HIV-1 K103N Transmitted Drug Resistance and Its Association with Efavirenz Use in South Korea.
Chin Bum Sik BS Shin Hyoung-Shik HS Kim Gayeon G Wagner Gabriel A GA Gianella Sara S Smith Davey M DM
AIDS research and human retroviruses 20150428 6
Previous studies reported a relatively low prevalence of transmitted drug resistance (TDR) in South Korea (<5%). A genotypic resistance test was performed on 131 treatment-naive HIV-1-infected individuals from February 2013 to February 2014. Eleven individuals (8.4%) presented TDR, of whom eight had K103N, revealing a significant increase in K103N TDR compared to previous studies (p<0.001). Using phylogenetic analysis, we identified three distinct clustering pairs with genetic relativeness and a ...[more]
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