Ontology highlight
ABSTRACT:
SUBMITTER: Mohammadzadeh-Vardin M
PROVIDER: S-EPMC4517083 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Mohammadzadeh-Vardin Mohammad M Habibi Roudkenar Mehryar M Jahanian-Najafabadi Ali A
Advanced pharmaceutical bulletin 20150601 2
<h4>Purpose</h4>Recent developments in the field of cell therapy have led to a renewed interest in treatment of acute kidney injury (AKI). However, the early death of transplanted mesenchymal stem cells (MSCs) in stressful microenvironment of a recipient tissue is a major problem with this kind of treatment. The objective of this study was to determine whether overexpression of a cytoprotective factor, nuclear factor erythroid-2 related factor 2 (Nrf2), in MSCs could protect rats against AKI.<h4 ...[more]